癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DGCR2 Rabbit pAb
DGCR2 Rabbit pAb
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P98153 |
| Reactivity | Rat, Rabbit, Zebrafish |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 60811 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DGCR2 |
| Epitope Specificity | 151-250/550 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane; Single pass type I membrane protein. |
| SIMILARITY | Contains 1 C-type lectin domain. Contains 1 LDL-receptor class A domain. Contains 1 VWFC domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The DGCR2 gene encodes a novel putative adhesion receptor protein, which may play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. |
| Gene ID | 9993 |
|---|---|
| Other Names | Integral membrane protein DGCR2/IDD, DGCR2, IDD, KIAA0163 |
| Target/Specificity | Predominantly expressed in brain, heart, lung and fetal kidney. Low levels in liver and adult kidney. |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | DGCR2 |
|---|---|
| Synonyms | IDD, KIAA0163 |
| Function | Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Predominantly expressed in brain, heart, lung and fetal kidney. Low levels in liver and adult kidney |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The DGCR2 gene encodes a novel putative adhesion receptor protein, which may play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22.
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