癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GIMAP1 Rabbit pAb
GIMAP1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8WWP7 |
| Reactivity | Rat |
| Predicted | Human, Mouse, Rabbit, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34369 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GIMAP1 |
| Epitope Specificity | 31-130/306 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The GTPase of the immunity-associated protein (GIMAP) family of proteins include seven members that are expressed by genes residing on human chromosome 7. GIMAP proteins have been implicated in the regulation of lymphomyeloid cell survival. GIMAP1 (GTPase, IMAP family member 1), also known as IMAP1 (immunity-associated protein 1), HIMAP1 or IMAP38, is a 306 amino acid single-pass type IV membrane protein of the endoplasmic reticulum (ER) belonging to the GIMAP family. Encoded by a gene located on human chromosome 7, GIMAP1 is expressed primarily in spleen with lower levels found in lymph node. Chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. |
| Gene ID | 170575 |
|---|---|
| Other Names | GTPase IMAP family member 1, Immunity-associated protein 1, hIMAP1, GIMAP1, IMAP1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GIMAP1 |
|---|---|
| Synonyms | IMAP1 |
| Function | May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P70224}; Single-pass type IV membrane protein. Golgi apparatus membrane {ECO:0000250|UniProtKB:P70224}; Single-pass type IV membrane protein |
| Tissue Location | Predominantly expressed in the spleen and to a lesser extent in the lymph nodes. Detected in T-cells |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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