癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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T2R38 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 1
- 实验流程
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | P59533 |
| Reactivity | Human, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 37892 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human T2R38/TAS2R38 |
| Epitope Specificity | 151-250/333 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the G-protein coupled receptor T2R family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The sense of taste is essential for the survival of organisms. For example, the ability to identify sweet-tasting foods enables animals to seek out food with high nutritive value, whereas the ability to identify bitter substances enables them to avoid the ingestion of potentially harmful substances. A family of integral membrane proteins are involved in taste perception and include T1R, which is involved in sweet taste perception and T2R, which is involved in bitter taste perception. Both types of taste receptors couple to various G proteins to initiate signal transduction cascades. Specifically, T2R38 is expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Variations in T2R38 are associated with the ability to taste the bitter chemical phenylthiocarbamide (PTC), also called thiourea tasting. |
| Gene ID | 5726 |
|---|---|
| Other Names | Taste receptor type 2 member 38, T2R38, PTC bitter taste receptor, Taste receptor type 2 member 61, T2R61, TAS2R38, PTC |
| Target/Specificity | Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4) with 1% BSA, 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | TAS2R38 |
|---|---|
| Synonyms | PTC |
| Function | Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). |
| Cellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed in testis (PubMed:16720576). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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