癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CASD1/C7orf12 Rabbit pAb
CASD1/C7orf12 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
| Primary Accession | Q96PB1 |
|---|---|
| Predicted | Rat, Pig, Dog, Human, Mouse, Chicken, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 91680 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CASD1/C7orf12 |
| Epitope Specificity | 201-300/797 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Golgi apparatus, Golgi apparatus membrane, Multi-pass membrane protein |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Gene ID | 64921 |
|---|---|
| Other Names | N-acetylneuraminate (7)9-O-acetyltransferase, 2.3.1.45, CAS1 domain-containing protein 1, CAS1 protein, Cas1p, Sialate O-acetyltransferase, SOAT, CASD1 (HGNC:16014), C7orf12 |
| Dilution | ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CASD1 (HGNC:16014) |
|---|---|
| Synonyms | C7orf12 |
| Function | Key enzyme in the biosynthesis of O-acetylated (O-Ac) sialoglycans such as gangliosides O-AcGD3 and O-AcGD2, which affect various processes such as cell-cell interactions, host-pathogen recognition (PubMed:20947662, PubMed:26169044, PubMed:34208013). Catalyzes the transfer of an acetyl group from a donor, the acetyl- coenzyme-A molecule (acetyl-CoA), to the C7/8/9 OH-position of a sialic acid residue (PubMed:20947662, PubMed:26169044). The primary site of O- acetyl group transfer on sialic acid seems to depend on cell type and can be C7, from which the O-acetyl group could subsequently migrate to the C8 and then to the C9 position, or at C9 with possibility of migrating to the C8 and then to the C7 position (PubMed:20947662, PubMed:26169044). Together with ST8SIA1 (GD3 synthase) it increases the levels of ganglioside Ac-O-7-GD3 (PubMed:20947662). Can transfer the acetyl group from acetyl-CoA to free sialate (N-acetylneuraminate, Neu5Ac) in vitro, but has preferred substrate specificity for CMP- activated sialate (CMP-Neu5Ac), resulting in the formation of 9-O- acetylated CMP-Neu5Ac (CMP-Neu5,9Ac2) (PubMed:26169044). CMP-Neu5,9Ac2 may be used by sialyltransferases as a sialate donor for glycoconjugate acceptors such as ganglioside GD3 (PubMed:26169044). O-acetylation at position C9 of ganglioside GD3 can counteract the pro-apoptotic effects of the ganglioside GD3 in tumor cells (PubMed:12486096). |
| Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in peripheral B lymphocytes. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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