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FAR1 Rabbit pAb
FAR1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8WVX9 |
| Predicted | Rat, Pig, Dog, Human, Mouse, Rabbit, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59357 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human FAR1 |
| Epitope Specificity | 55-160/515 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Peroxisome membrane; Single-pass membrane protein (Potential). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The conversion of fatty acids to fatty alcohols is required for the synthesis of wax monoesters and ether lipids. Members of the fatty acyl-CoA reductase family, including FAR1 (fatty acyl-CoA reductase 1) and FAR2 (fatty acyl-CoA reductase 2), play a role in catalyzing the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols. FAR1, also known as male sterility domain-containing protein 2 (MLSTD2) or short chain dehydrogenase/reductase family 10E, member 1 (SDR10E1), is a 515 amino acid single-pass membrane protein that localizes to the peroxisome, FAR1 is suggested to be essential for providing fatty alcohols required for ether bond formation in ether glycerophospholipid synthesis. The gene encoding FAR1 is located on chromosome 11, which comprises nearly 4% of the human genome. |
| Gene ID | 84188 |
|---|---|
| Other Names | Fatty acyl-CoA reductase 1, FAR1, 1.2.1.84, Male sterility domain-containing protein 2 {ECO:0000312|HGNC:HGNC:26222}, FAR1 (HGNC:26222) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FAR1 (HGNC:26222) |
|---|---|
| Function | Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:24108123, PubMed:35238077). It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (PubMed:20071337, PubMed:24108123, PubMed:33239752). In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity) (PubMed:24108123, PubMed:35238077). |
| Cellular Location | Peroxisome membrane; Single-pass membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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