Anti-DUSP22 Antibody
Rabbit polyclonal antibody to DUSP22
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- 实验流程
- 背景知识
Application ![]()
| WB, IF/IC |
---|---|
Primary Accession | Q9NRW4 |
Other Accession | Q99N11 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 20910 Da |
Gene ID | 56940 |
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Other Names | JSP1; LMWDSP2; MKPX; Dual specificity protein phosphatase 22; JNK-stimulatory phosphatase-1; JSP-1; Low molecular weight dual specificity phosphatase 2; LMW-DSP2; Mitogen-activated protein kinase phosphatase x; MAP kinase phosphatase x; MKP-x |
Target/Specificity | Recognizes endogenous levels of DUSP22 protein. |
Dilution | WB~~WB (1/500 - 1/1000), IF/IC (1/100 - 1/500) IF/IC~~N/A |
Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | DUSP22 |
---|---|
Synonyms | JSP1, LMWDSP2, MKPX |
Function | Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues (PubMed:24714587, PubMed:38225265). Activates the JNK signaling pathway (PubMed:11717427). Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2 (PubMed:24714587, PubMed:38225265). Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2 (PubMed:38225265). Dephosphorylates and thereby inactivates tyrosine kinase LCK (PubMed:24714587). Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK (PubMed:38225265). May play a role in B-cell receptor (BCR) signaling and B-cell function (By similarity). |
Cellular Location | Cytoplasm. |
Tissue Location | Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human DUSP22. The exact sequence is proprietary.

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Cat# AP60269