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>   首页   >   产品   >   一抗   >   其他   >   Anti-Endothelin 1 Antibody   

Anti-Endothelin 1 Antibody

Rabbit polyclonal antibody to Endothelin 1

     
  • 1 - Anti-Endothelin 1 Antibody AP60271
    Western blot analysis of Endothelin 1 expression in HEK293T (A), LOVO (B), H1792 (C), mouse testis (D) whole cell lysates.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P05305
Other Accession P22387
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 24425 Da
Additional Information
Gene ID 1906
Other Names Endothelin-1; Preproendothelin-1; PPET1
Target/Specificity Recognizes endogenous levels of Endothelin 1 protein.
Dilution WB~~WB (1/500 - 1/1000)
Format Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide.
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name EDN1
Function Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (By similarity). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity).
Cellular Location Secreted.
Tissue Location Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Endothelin 1. The exact sequence is proprietary.

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