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Anti-Kappa Opioid Receptor (pS369) Antibody

Rabbit polyclonal antibody to Kappa Opioid Receptor (pS369)

     
  • 1 - Anti-Kappa Opioid Receptor (pS369) Antibody AP60496
    Western blot analysis of Kappa Opioid Receptor (pS369) expression in PC12 (A), mouse kidney (B), mouse muscle (C), rat kidney (D), rat muscle (E) whole cell lysates.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P41145
Other Accession P33534
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 42645 Da
Additional Information
Gene ID 4986
Other Names OPRK1; OPRK; Kappa-type opioid receptor; K-OR-1; KOR-1
Target/Specificity Recognizes endogenous levels of Kappa Opioid Receptor (pS369) protein.
Dilution WB~~WB (1/500 - 1/1000)
Format Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide.
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name OPRK1
Synonyms OPRK
Function G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain and placenta.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Kappa Opioid Receptor (pS369). The exact sequence is proprietary.

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