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为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-GPR37L1 Antibody
Rabbit polyclonal antibody to GPR37L1
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | O60883 |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52771 Da |
| Gene ID | 9283 |
|---|---|
| Other Names | ETBRLP2; Prosaposin receptor GPR37L1; Endothelin B receptor-like protein 2; ETBR-LP-2; G-protein coupled receptor 37-like 1 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GPR37L1. The exact sequence is proprietary. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | GPR37L1 |
|---|---|
| Synonyms | ETBRLP2 |
| Function | G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q99JG2}; Multi-pass membrane protein. Note=Associates with the basal membrane of Bergmann glia cell primary cilia. {ECO:0000250|UniProtKB:Q99JG2} |
| Tissue Location | Expressed in primary cortical astrocytes (at protein level) (PubMed:23690594). Expressed in the central nervous system (PubMed:9539149). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GPR37L1. The exact sequence is proprietary.
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¥ 1,500.00
Cat# AP60800
