癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LAF4 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | P51826 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 133503 Da |
| Antigen Region | 1197-1227 aa |
| Gene ID | 3899 |
|---|---|
| Other Names | AF4/FMR2 family member 3, Lymphoid nuclear protein related to AF4, Protein LAF-4, AFF3, LAF4 |
| Target/Specificity | This LAF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1197-1227 amino acids from the C-terminal region of human LAF4. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LAF4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AFF3 {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:6473} |
|---|---|
| Function | Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double- stranded DNA. |
| Cellular Location | Nucleus. |
| Tissue Location | Preferentially expressed in lymphoid tissues, highest levels being found in the thymus |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Lymphoid nuclear protein related to AF4 (LAF4) is related to MLLT2 which is also referred to as AF4. LAF4 is a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of LAF4 has defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis.
REFERENCES
Hiwatari, M., et al., Oncogene 22(18):2851-2855 (2003).
von Bergh, A.R., et al., Genes Chromosomes Cancer 35(1):92-96 (2002).
Liao, X., et al., Mamm. Genome 7(6):467-468 (1996).
Ma, C., et al., Blood 87(2):734-745 (1996).
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