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Anti-Bestrophin Antibody
Rabbit polyclonal antibody to Bestrophin
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | O76090 |
| Other Accession | O88870 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 67684 Da |
| Gene ID | 7439 |
|---|---|
| Other Names | VMD2; Bestrophin-1; TU15B; Vitelliform macular dystrophy protein 2 |
| Target/Specificity | Recognizes endogenous levels of Bestrophin protein. |
| Dilution | WB~~1:1000 |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | BEST1 (HGNC:12703) |
|---|---|
| Function | Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+) (PubMed:11904445, PubMed:12907679, PubMed:18179881, PubMed:18400985, PubMed:19853238, PubMed:21330666, PubMed:26200502, PubMed:26720466, PubMed:35789156). Allows the movement of chloride and hydrogencarbonate (PubMed:11904445, PubMed:12907679, PubMed:18179881, PubMed:18400985, PubMed:19853238, PubMed:21330666, PubMed:26200502, PubMed:26720466, PubMed:35789156). Found in a partially open conformation leading to significantly smaller chloride movement (PubMed:35789156). Upon F2R/PAR-1 activation, the sequestered calcium is released into the cytosol of astrocytes, leading to the (Ca2+)-dependent release of L- glutamate into the synaptic cleft that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (By similarity). Upon activation of the norepinephrine- alpha-1 adrenergic receptor signaling pathway, transports as well D- serine than L-glutamate in a (Ca2+)-dependent manner, leading to activation of adjacent NMDAR receptors and therefore regulates the heterosynaptic long-term depression and metaplasticity during initial memory acquisition (By similarity). Releases the 4-aminobutanoate neurotransmitter in a (Ca2+)-dependent manner, and participates in its tonic release from cerebellar glial cells (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein Note=Localized at the surface membrane of microdomains adjacent to glutamatergic synapses. {ECO:0000250|UniProtKB:O88870} |
| Tissue Location | Predominantly expressed in the basolateral membrane of the retinal pigment epithelium |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Recombinant full length protein of human Bestrophin
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