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>   首页   >   产品   >   一抗   >   Ubiquitin E3 Ligases (RING Domain) Antibodies   >   MLL3 Antibody (C-term)   

MLL3 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MLL3 Antibody (C-term) AP6184a
    Western blot analysis of MLL3 Antibody (C-term) (Cat.#AP6184a) in HEK 293 cell line lysates. MLL3 (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q8NEZ4
Other Accession Q8BRH4
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 541370 Da
Additional Information
Gene ID 58508
Other Names Histone-lysine N-methyltransferase 2C, Lysine N-methyltransferase 2C, Homologous to ALR protein, Myeloid/lymphoid or mixed-lineage leukemia protein 3, KMT2C, HALR, KIAA1506, MLL3
Target/Specificity This MLL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4345-4374 amino acids from the C-terminal region of human MLL3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMLL3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KMT2C
Synonyms HALR, KIAA1506, MLL3
Function Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:24081332, PubMed:22266653). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332).
Cellular Location Nucleus.
Tissue Location Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver
Research Areas

BACKGROUND

The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL family, including MLL3. The MLL SET domain is a histone H3 Lys4 (K4)-specific methyltransferase whose activity is stimulated with acetylated H3 peptides. MLL3 maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia. The deduced MLL3 4,911-amino acid protein is more closely related to MLL2 than to MLL1 or MLL4. MLL3 has 6 plant homeodomain (PHD) fingers preceded by a cys-rich ZNF1 domain in its N terminus; a high mobility group (HMG) box, an ATPase alpha-beta signature, and a leucine zipper motif in its central region; and 2 C-terminal FY (phe-tyr) motifs and the SET domain preceded by a ZNF2 domain in its C terminus. The predicted protein also contains several putative nuclear localization motifs. Isoform II lacks ZNF1 and the PHD.

REFERENCES

Ota, T., et al., Nat. Genet. 36(1):40-45 (2004). Hillier, L.W., et al., Nature 424(6945):157-164 (2003). Goo, Y.-H., et al., Mol. Cell. Biol. 23(1):140-149 (2003). Tan, Y.C., et al., Cancer Detect. Prev. 25(5):454-469 (2001). Nagase, T., et al., DNA Res. 7(2):143-150 (2000).

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