癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NRG2 Antibody (C-term) 精选
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | O14511 |
| Other Accession | O35569 |
| Reactivity | Human |
| Predicted | Rat, Mouse, Bovine, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 91679 Da |
| Antigen Region | 830~855 aa |
| Gene ID | 9542 |
|---|---|
| Other Names | Pro-neuregulin-2, membrane-bound isoform, Pro-NRG2, Neuregulin-2, NRG-2, Divergent of neuregulin-1, DON-1, Neural- and thymus-derived activator for ERBB kinases, NTAK, NRG2, NTAK |
| Target/Specificity | This NRG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-389 amino acids from the C-terminal region of human NRG2. |
| Dilution | IHC-P~~1:100~500 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NRG2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NRG2 |
|---|---|
| Synonyms | NTAK |
| Function | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. |
| Cellular Location | [Pro-neuregulin-2, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active. |
| Tissue Location | Restricted to the cerebellum in the adult. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. There are six NRG2 alternatively spliced transcripts which are variable between the epidermal growth factor-like (EGF-like) and the transmembrane domains. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease.
REFERENCES
Yamada, K., et al., Gene 255(1):15-24 (2000). Ring, H.Z., et al., Hum. Genet. 104(4):326-332 (1999). Busfield, S.J., et al., Mol. Cell. Biol. 17(7):4007-4014 (1997). Higashiyama, S., et al., J. Biochem. 122(3):675-680 (1997). Carraway, K.L. III, et al., Nature 387(6632):512-516 (1997).
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