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14-3-3 ε Polyclonal Antibody

     
  • 1 - 14-3-3 ε Polyclonal Antibody AP63500
    Western blot analysis of 1) Mouse Brain, 2) Rat Brain using 14-3-3 ε Polyclonal Antibody.. Secondary antibody was diluted at 1:20000
  • 14 - 14-3-3 ε Polyclonal Antibody AP63500
    Immunohistochemical analysis of paraffin-embedded Rat BrainTissue using 14-3-3 ε Polyclonal Antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P
Primary Accession P62258
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 29174 Da
Additional Information
Gene ID 7531
Other Names YWHAE; 14-3-3 protein epsilon; 14-3-3E
Dilution WB~~WB: 1:1000 IHC:1:200-500
IHC-P~~WB: 1:1000 IHC:1:200-500
Format PBS, pH 7.4, containing 0.09% (W/V) sodium azide as Preservative and 50% Glycerol.
Storage Conditions-20℃
Protein Information
Name YWHAE
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448).
Cellular Location Nucleus. Cytoplasm Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326).

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