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GABA A Receptor α2 Polyclonal Antibody

     
  • 1 - GABA A Receptor α2 Polyclonal Antibody AP63678
    Western blot analysis of 1) Mouse Brain Tissue, 2)Rat Brain Tissue with GABA A Receptor α2 Rabbit pAb diluted at 1:2,000.
  • 14 - GABA A Receptor α2 Polyclonal Antibody AP63678
    Immunohistochemical analysis of paraffin-embedded Rat BrainTissue using GABA A Receptor α2 Rabbit pAb diluted at 1:200.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P
Primary Accession P47869
Reactivity Human, Rat, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 51326 Da
Additional Information
Gene ID 2555
Other Names Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2)
Dilution WB~~WB 1:1000-2000, IHC 1:100-200
IHC-P~~WB 1:1000-2000, IHC 1:100-200
Format Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide.
Storage Conditions-20℃
Protein Information
Name GABRA2 (HGNC:4076)
Function Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:29961870, PubMed:31032849). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10449790). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity).
Cellular Location Postsynaptic cell membrane {ECO:0000250|UniProtKB:P26048}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P26048}; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P23576}. Cell projection, dendrite {ECO:0000250|UniProtKB:P26048}
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

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