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ACTR2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - ACTR2 Antibody (Center) AP6533c
    ACTR2 Antibody (Center) (Cat. #AP6533c) western blot analysis in Hela,Jurkat cell line lysates (35ug/lane).This demonstrates the ACTR2 antibody detected the ACTR2 protein (arrow).
  • 14 - ACTR2 Antibody (Center) AP6533c
    Formalin-fixed and paraffin-embedded human skeletal muscle reacted with ACTR2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • 4 - ACTR2 Antibody (Center) AP6533c
    ACTR2 Antibody (Center) (Cat. #AP6533c) flow cytometric analysis of A375 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, FC, WB, E
Primary Accession P61160
Other Accession Q5M7U6, P61161, P53488, A7MB62, Q7ZTP2
Reactivity Human, Rat, Mouse
Predicted Xenopus, Bovine, Chicken, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 44761 Da
Antigen Region 191-219 aa
Additional Information
Gene ID 10097
Other Names Actin-related protein 2, Actin-like protein 2, ACTR2, ARP2
Target/Specificity This ACTR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-219 amino acids from the Central region of human ACTR2.
Dilution IHC-P~~1:100~500
FC~~1:10~50
WB~~1:1000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsACTR2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACTR2
Synonyms ARP2
Function ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Cellular Location Cytoplasm, cytoskeleton. Cell projection. Nucleus
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

ACTR2 is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion.

REFERENCES

Gonzalez,V., Cell Host Microbe 5 (3), 259-272 (2009)
Weisswange,I., Nature 458 (7234), 87-91 (2009)

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