癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DCN Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
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Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | P07585 |
| Other Accession | Q9XSD9, P21793 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39747 Da |
| Antigen Region | 122-150 aa |
| Gene ID | 1634 |
|---|---|
| Other Names | Decorin, Bone proteoglycan II, PG-S2, PG40, DCN, SLRR1B |
| Target/Specificity | This DCN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-150 amino acids from the Central region of human DCN. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DCN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DCN |
|---|---|
| Synonyms | SLRR1B |
| Function | May affect the rate of fibrils formation. |
| Cellular Location | Secreted, extracellular space, extracellular matrix. Secreted |
| Tissue Location | Detected in placenta (at protein level) (PubMed:32337544). Detected in cerebrospinal fluid, fibroblasts and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
DCN is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines.
REFERENCES
Goldoni,S., J. Cell Biol. 185 (4), 743-754 (2009)
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