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>   首页   >   产品   >   一抗   >   精选抗体   >   磷酸化抗体   >   WAVE1 (phospho Tyr125) Polyclonal Antibody   

WAVE1 (phospho Tyr125) Polyclonal Antibody

     
  • 1 - WAVE1 (phospho Tyr125) Polyclonal Antibody AP67612
    Western Blot analysis of 3T3 cells using Phospho-WAVE1 (Y125) Polyclonal Antibody
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, IF
Primary Accession Q92558
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 61652 Da
Additional Information
Gene ID 8936
Other Names WASF1; KIAA0269; SCAR1; WAVE1; Wiskott-Aldrich syndrome protein family member 1; WASP family protein member 1; Protein WAVE-1; Verprolin homology domain-containing protein 1
Dilution WB~~Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
IHC-P~~N/A
IF~~1:50~200
Format Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide.
Storage Conditions-20℃
Protein Information
Name WASF1 (HGNC:12732)
Synonyms KIAA0269, SCAR1, WAVE1
Function Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568).
Cellular Location Cytoplasm, cytoskeleton. Synapse {ECO:0000250|UniProtKB:Q5BJU7} Cell junction, focal adhesion. Note=Dot- like pattern in the cytoplasm. Concentrated in Rac-regulated membrane- ruffling areas (PubMed:9889097). Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2 (PubMed:18559503). In neurons, colocalizes with activated NTRK2 after BDNF addition in endocytic sites through the association with TMEM108 (By similarity). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9889097}
Tissue Location Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF- NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).

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