NOS3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
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Application ![]()
| WB, IHC-P, IF, FC, E |
---|---|
Primary Accession | P29474 |
Other Accession | Q28969, P29473 |
Reactivity | Human, Rat, Mouse |
Predicted | Pig, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 133275 Da |
Antigen Region | 48-75 aa |
Gene ID | 4846 |
---|---|
Other Names | Nitric oxide synthase, endothelial, Constitutive NOS, cNOS, EC-NOS, Endothelial NOS, eNOS, NOS type III, NOSIII, NOS3 |
Target/Specificity | This NOS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-75 amino acids from the N-terminal region of human NOS3. |
Dilution | WB~~1:1000 IHC-P~~1:100~500 IF~~1:10~50 FC~~1:10~50 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NOS3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NOS3 (HGNC:7876) |
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Function | Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. |
Cellular Location | Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity |
Tissue Location | Platelets, placenta, liver and kidney. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.

Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases.
REFERENCES
Rikova,K., et.al., Cell 131 (6), 1190-1203 (2007)

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Discontinued
Cat# AP6963a
Size:
50 µl
100 µl
200 µl
400 µl
Price:
¥ 1,250.00
¥ 2,050.00
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¥ 4,550.00
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