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Gasdermin C Polyclonal Antibody

     
  • 1 - Gasdermin C Polyclonal Antibody AP70038
    Western Blot analysis of various cells using Gasdermin C Polyclonal Antibody diluted at 1:500
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q9BYG8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 57692 Da
Additional Information
Gene ID 56169
Other Names GSDMC; MLZE; Gasdermin-C; Melanoma-derived leucine zipper-containing extranuclear factor
Dilution WB~~Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Format Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide.
Storage Conditions-20℃
Protein Information
Name GSDMC {ECO:0000303|PubMed:17350798, ECO:0000312|HGNC:HGNC:7151}
Function [Gasdermin-C]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis.
Cellular Location [Gasdermin-C]: Cytoplasm, cytosol
Tissue Location Expressed mainly in trachea and spleen (PubMed:11223543). In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium (PubMed:19051310).
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown (Probable).

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