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>   首页   >   产品   >   一抗   >   其他   >   Netrin-1 Polyclonal Antibody   

Netrin-1 Polyclonal Antibody

     
  • 1 - Netrin-1 Polyclonal Antibody AP73705
    Western Blot analysis of HeLa cells using Netrin-1 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000
  • 14 - Netrin-1 Polyclonal Antibody AP73705
    Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100
  • 14 - Netrin-1 Polyclonal Antibody AP73705
    Immunohistochemical analysis of paraffin-embedded mouse-brain, antibody was diluted at 1:100
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P
Primary Accession O95631
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 67748 Da
Additional Information
Gene ID 9423
Other Names NTN1; NTN1L; Netrin-1; Epididymis tissue protein Li 131P
Dilution WB~~Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/20000. Not yet tested in other applications.
IHC-P~~Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/20000. Not yet tested in other applications.
Format Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide.
Storage Conditions-20℃
Protein Information
Name NTN1
Synonyms NTN1L
Function Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335).
Cellular Location Secreted. Cytoplasm. Note=Mainly secreted
Tissue Location Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level).
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.

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