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Parathyroid hormone/parathyroid hormone-related peptide receptor Polyclonal Antibody
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- 实验流程
- 背景知识
Application 
| WB, IHC-P, IF, ICC, E |
|---|---|
| Primary Accession | Q03431 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 66361 Da |
| Gene ID | 5745 |
|---|---|
| Other Names | Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) |
| Dilution | WB~~WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000 IHC-P~~WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000 IF~~1:50~200 ICC~~N/A E~~N/A |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PTH1R {ECO:0000303|PubMed:10913300, ECO:0000312|HGNC:HGNC:9608} |
|---|---|
| Function | G protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed:30975883, PubMed:35932760, PubMed:8397094). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (PubMed:30975883, PubMed:35932760). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:20172855, PubMed:30975883, PubMed:35932760). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (PubMed:35932760). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in most tissues. Most abundant in kidney, bone and liver. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
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