Parathyroid hormone/parathyroid hormone-related peptide receptor Polyclonal Antibody

Western blot analysis of MCF7 Cell Lysate, antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000
Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200

Western blot analysis of MCF7 Cell Lysate, antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P
Primary Accession	Q03431
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Calculated MW	66361 Da

Additional Information
Gene ID	5745
Other Names	Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor)
Dilution	WB~~WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000 IHC-P~~N/A
Format	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide.
Storage Conditions	-20℃

Protein Information
Name	PTH1R {ECO:0000303\|PubMed:10913300, ECO:0000312\|HGNC:HGNC:9608}
Function	G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed:30975883, PubMed:35932760, PubMed:8397094). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (PubMed:30975883, PubMed:35932760). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:20172855, PubMed:30975883, PubMed:35932760). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (PubMed:35932760).
Cellular Location	Cell membrane; Multi-pass membrane protein
Tissue Location	Expressed in most tissues. Most abundant in kidney, bone and liver.

Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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¥ 1,500.00

Cat# AP74039

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