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TTN Polyclonal Antibody

     
  • 14 - TTN Polyclonal Antibody AP74183
    Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200
  • 14 - TTN Polyclonal Antibody AP74183
    Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200
  • 14 - TTN Polyclonal Antibody AP74183
    Immunohistochemical analysis of paraffin-embedded human-skeletal-muscle, antibody was diluted at 1:200
  • 14 - TTN Polyclonal Antibody AP74183
    Immunohistochemical analysis of paraffin-embedded human-skeletal-muscle, antibody was diluted at 1:200
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P
Primary Accession Q8WZ42
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 3816030 Da
Additional Information
Gene ID 7273
Other Names Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14)
Dilution IHC-P~~IHC-p 1:50-200, ELISA 1:10000-20000
Format Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide.
Storage Conditions-20℃
Protein Information
Name TTN
Function Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.
Cellular Location Cytoplasm. Nucleus
Tissue Location Isoforms 3, 7 and 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in skeletal muscle (at protein level)
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.

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