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>   首页   >   产品   >   一抗   >   癌症   >   CAMK2A Antibody (C-term E370)   

CAMK2A Antibody (C-term E370)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CAMK2A Antibody (C-term E370) AP7418b
    Western blot analysis of anti-CAMK2A Antibody (C-term E370) (Cat.#AP7418b) in 293 cell line lysates (35ug/lane). CAMK2A(arrow) was detected using the purified Pab.
  • 1 - CAMK2A Antibody (C-term E370) AP7418b
    Western blot analysis of CAMK2A (arrow) using rabbit polyclonal CAMK2A Antibody (C-term E370) (Cat.#AP7418b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CAMK2A gene (Lane 2).
  • 14 - CAMK2A Antibody (C-term E370) AP7418b
    Formalin-fixed and paraffin-embedded human brain tissue reacted with CAMK2A (C-term E370) (Cat.#AP7418b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q9UQM7
Other Accession P11275, P11798
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 54088 Da
Antigen Region 344-371 aa
Additional Information
Gene ID 815
Other Names Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, CAMK2A, CAMKA, KIAA0968
Target/Specificity This CAMK2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 344-371 amino acids from the C-terminal region of human CAMK2A.
Dilution WB~~1:1000
IHC-P~~1:100~500
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCAMK2A Antibody (C-term E370) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAMK2A
Synonyms CAMKA, KIAA0968
Function Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK- STAT signaling pathway (PubMed:11972023). In response to interferon- beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). Acts as a negative regulator of 2- arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity).
Cellular Location Synapse {ECO:0000250|UniProtKB:P11275}. Postsynaptic density {ECO:0000250|UniProtKB:P11275}. Cell projection, dendritic spine. Cell projection, dendrite. Note=Postsynaptic lipid rafts {ECO:0000250|UniProtKB:P11275}
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

CAMK2A belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by the gene for CAMK2A is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity.

REFERENCES

Lee,C.W., Mol. Pharmacol. 73 (5), 1454-1464 (2008)
Yuan,K., Lab. Invest. 87 (9), 938-950 (2007)

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