癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CD242 Polyclonal Antibody
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Application 
| IHC-P, IF, ICC, E |
|---|---|
| Primary Accession | Q14773 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 29265 Da |
| Gene ID | 3386 |
|---|---|
| Other Names | Intercellular adhesion molecule 4 (ICAM-4) (Landsteiner-Wiener blood group glycoprotein) (LW blood group protein) (CD antigen CD242) |
| Dilution | IHC-P~~IHC-p 1:50-200, ELISA 1:10000-20000 IF~~1:50~200 ICC~~N/A E~~N/A |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
| Storage Conditions | -20℃ |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ICAM4 (HGNC:5347) |
|---|---|
| Function | Functions as a receptor ligand for the monocyte/macrophage- specific ITGAX:ITGB2 integrin complex and mediates erythrophagocytosis (PubMed:16985175). Receptor ligand of the platelet-specific ITGA2B:ITGB3 integrin complex involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets (PubMed:12477717, PubMed:15355350). In vitro, is also a receptor ligand of multiple integrin receptors complexes such ITGAL:ITGB2, ITGAM:ITGB2, ITGA5:ITGB1, ITGA5:ITGB3 and ITGA5:ITGB5 integrin complexes (PubMed:10846180, PubMed:11435317, PubMed:15355350). |
| Cellular Location | [Isoform Long]: Cell membrane; Single-pass type I membrane protein Cell membrane {ECO:0000250|UniProtKB:Q9ERM2}; Single-pass type I membrane protein |
| Tissue Location | Erythrocytes.. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.
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