癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ADAMTS13 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q76LX8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 153604 Da |
| Antigen Region | 829-858 aa |
| Gene ID | 11093 |
|---|---|
| Other Names | A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, von Willebrand factor-cleaving protease, vWF-CP, vWF-cleaving protease, ADAMTS13, C9orf8 |
| Target/Specificity | This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-858 amino acids from the Central region of human ADAMTS13. |
| Dilution | WB~~1:500 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ADAMTS13 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADAMTS13 |
|---|---|
| Synonyms | C9orf8 |
| Function | Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. |
| Cellular Location | Secreted. Note=Secretion enhanced by O-fucosylation of TSP type-1 repeats |
| Tissue Location | Plasma. Expressed primarily in liver. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
REFERENCES
Zheng X., Chung D., Takayama T.K.J. Biol. Chem. 276:41059-41063(2001)
Levy G.G., Nichols W.C.Nature 413:488-494(2001)
Cal S., Obaya A.J., Llamazares M., Garabaya C.Gene 283:49-62(2002)
Zheng X., Nishio K., Majerus E.M.J. Biol. Chem. 278:30136-30141(2003)
Anderson P.J., Kokame K., Sadler J.E.J. Biol. Chem. 281:850-857(2006)
Pimanda J.E., Maekawa A., Wind T.Blood 103:627-629(2004)
Plaimauer B., Fuhrmann J., Mohr G.Blood 107:118-125(2006)
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