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>   首页   >   产品   >   一抗   >   癌症   >   ADAMTS4 Antibody (C-term)   

ADAMTS4 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ADAMTS4 Antibody (C-term) AP7439b
    Anti-ADAMTS4 Antibody (C-term) at 1:2000 dilution + Human lung lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 90 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O75173
Reactivity Human, Rat, Mouse
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 90197 Da
Antigen Region 705-736 aa
Additional Information
Gene ID 9507
Other Names A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, ADMP-1, Aggrecanase-1, ADAMTS4, KIAA0688
Target/Specificity This ADAMTS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 705-736 amino acids from the C-terminal region of human ADAMTS4.
Dilution WB~~1:2000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsADAMTS4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADAMTS4
Synonyms KIAA0688
Function Cleaves aggrecan, a cartilage proteoglycan, at the '392- Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391). May play an important role in the destruction of aggrecan in arthritic diseases. Could be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Expressed in brain, lung and heart (PubMed:23897278). Expressed at very low level in placenta and skeletal muscles (PubMed:23897278). Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278)
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

REFERENCES

Tortorella M.D., Burn T.C.Science 284:1664-1666(1999)
Tortorella M.D., Pratta M.A., Liu R.-Q.J. Biol. Chem. 275:25791-25797(2000)

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