Polyclonal Antibody to Interleukin 11 (IL11)

Interleukin 11

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB
Primary Accession	P47873
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Calculated MW	21522 Da

Additional Information
Gene ID	16156
Other Names	AGIF; Adipogenesis Inhibitory Factor; Oprelvekin
Target/Specificity	Mus musculus (Mouse)
Dilution	WB~~Western blotting: 0.5-2 µg/mL;1:500-2000<br/>Immunohistochemistry: 5-20 µg/mL;1:50-200<br/>Immunocytochemistry: 5-20 µg/mL;1:50-200<br/>Optimal working dilutions must be determined by end user.
Format	PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Storage	Store at -20 °C.Stable for 12 months from date of receipt

Protein Information
Name	Il11 {ECO:0000312\|MGI:MGI:107613}
Function	Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed:22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed:10026196, PubMed:23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed:22253262, PubMed:23948300). The interaction with the membrane- bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans- signaling' (By similarity).
Cellular Location	Secreted.