癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Polyclonal Antibody to Interleukin 11 (IL11)
Interleukin 11
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P47873 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 21522 Da |
| Gene ID | 16156 |
|---|---|
| Other Names | AGIF; Adipogenesis Inhibitory Factor; Oprelvekin |
| Target/Specificity | Mus musculus (Mouse) |
| Dilution | WB~~Western blotting: 0.5-2 µg/mL;1:500-2000<br/>Immunohistochemistry: 5-20 µg/mL;1:50-200<br/>Immunocytochemistry: 5-20 µg/mL;1:50-200<br/>Optimal working dilutions must be determined by end user. |
| Format | PBS, pH7.4, containing 0.02% NaN3, 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Il11 {ECO:0000312|MGI:MGI:107613} |
|---|---|
| Function | Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed:22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed:10026196, PubMed:23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed:22253262, PubMed:23948300). The interaction with the membrane- bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans- signaling' (By similarity). |
| Cellular Location | Secreted. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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