癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Polyclonal Antibody to Interleukin 18 (IL18)
Interleukin 18
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8QFQ8 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 22787 Da |
| Other Names | IGIF; IL-1g; IL1F4; IL1-F4; Interferon-Gamma-Inducing Factor; Interleukin-1 Family Member 4; Iboctadekin; Interleukin-1 Gamma |
|---|---|
| Target/Specificity | Chicken (Gallus) |
| Dilution | WB~~Western blotting: 0.5-2 µg/mL;<br/>Immunohistochemistry: 5-20 µg/mL;<br/>Immunocytochemistry: 5-20 µg/mL;<br/>Optimal working dilutions must be determined by end user. |
| Format | PBS, pH7.4, containing 0.02% NaN3, 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | IL18 |
|---|---|
| Function | Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q14116}. Secreted {ECO:0000250|UniProtKB:Q14116}. Note=The precursor is cytosolic. In response to inflammasome-activating signals, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10. {ECO:0000250|UniProtKB:Q14116} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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