癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Polyclonal Antibody to Nerve Growth Factor (NGF)
Nerve Growth Factor
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q29074 |
| Reactivity | Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 25276 Da |
| Other Names | NGFB; Beta-NGF; HSAN5; NGF-B; Beta-Nerve Growth Factor |
|---|---|
| Target/Specificity | Sus scrofa; Porcine (Pig) |
| Dilution | WB~~Western blotting: 0.5-2 µg/mL;1:250-1000 Immunohistochemistry: 5-20 µg/mL;1:25-100 Immunocytochemistry: 5-20 µg/mL;1:25-100 Optimal working dilutions must be determined by end user. |
| Format | PBS, pH7.4, containing 0.02% NaN3, 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NGF |
|---|---|
| Synonyms | NGFB |
| Function | Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:P01138}. Endosome lumen {ECO:0000250|UniProtKB:P01139}. Note=ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR {ECO:0000250|UniProtKB:P01139} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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