癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Polyclonal Antibody to Urocortin (UCN)
Urocortin
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P55089 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 13458 Da |
| Gene ID | 7349 |
|---|---|
| Other Names | UI; UROC; Urocortin 1; UCN1 |
| Target/Specificity | Homo sapiens (Human) |
| Dilution | WB~~Western blotting: 0.5-2 µg/mL;Immunohistochemistry: 5-20 µg/mL;Immunocytochemistry: 5-20 µg/mL;Optimal working dilutions must be determined by end user. |
| Format | 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | UCN {ECO:0000303|PubMed:9628819, ECO:0000312|HGNC:HGNC:12516} |
|---|---|
| Function | Hormone that plays a central role in whole body adaptation to stress (PubMed:20966082, PubMed:24290358, PubMed:32004470, PubMed:36335102, PubMed:8612563). Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptors CRHR1 and CRHR2 (PubMed:24290358, PubMed:26350463, PubMed:32004470, PubMed:36335102, PubMed:8612563). UCN-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus- pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:P55090}. |
| Tissue Location | Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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