癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Polyclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1)
Heat Shock Protein 90kDa Beta 1
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P08113 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 92476 Da |
| Gene ID | 22027 |
|---|---|
| Other Names | HSP90-B1; ECGP; GP96; GRP94; TRA1; Glycoprotein 96; Tumor Rejection Antigen(gp96)1;94 kDa glucose-regulated protein; Endoplasmin |
| Target/Specificity | Mus musculus (Mouse) |
| Dilution | WB~~Western blotting: 0.5-2 µg/mL;1:130-500 Immunohistochemistry: 5-20 µg/mL;1:13-50 Immunocytochemistry: 5-20 µg/mL;1:13-50 Optimal working dilutions must be determined by end user. |
| Format | PBS, pH7.4, containing 0.02% NaN3, 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Hsp90b1 |
|---|---|
| Function | ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:20865800, PubMed:23572575). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:20865800). Promotes folding and trafficking of TLR4 to the cell surface (By similarity). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity). |
| Cellular Location | Endoplasmic reticulum lumen. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P41148}. Melanosome {ECO:0000250|UniProtKB:P14625} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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