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> 首页 > 产品 > 一抗 > 其他 > Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg)
Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Gamma (PPARg)
Peroxisome Proliferator Activated Receptor Gamma
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | O18971 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 57579 Da |
| Gene ID | 281993 |
|---|---|
| Other Names | PPAR-G; PPARG1; PPARG2; NR1C3; Glitazone Receptor; Nuclear Receptor Subfamily 1 Group C Member 3 |
| Target/Specificity | Bos taurus; Bovine (Cattle) |
| Dilution | WB~~Western blotting: 0.5-2 µg/mL Immunohistochemistry: 5-20 µg/mL Immunocytochemistry: 5-20 µg/mL Optimal working dilutions must be determined by end user. |
| Format | 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PPARG |
|---|---|
| Synonyms | NR1C3 |
| Function | Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism, glucose homeostasis and beta-oxidation of fatty acids. Activated by lipid ligands: binds peroxisome proliferators, such as hypolipidemic drugs, and fatty acids, such as prostaglandin J2 metabolites. Ligand-binding results in a conformational change in the receptor, promoting dissociation of repressors and recruitment of coactivators, and subsequent activation of target gene expression. Specifically binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase (By similarity). Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses (By similarity). Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P37238}. Cytoplasm {ECO:0000250|UniProtKB:P37231}. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner (By similarity) NOCT enhances its nuclear translocation (By similarity) {ECO:0000250|UniProtKB:P37231, ECO:0000250|UniProtKB:P37238} |
| Tissue Location | Highest expression in adipose tissue. Lower in spleen and lung. Also detected in ovary, mammary gland and small intestine. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP74601
