癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Polyclonal Antibody to Pregnane X Receptor (PXR)
Pregnane X Receptor
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9R1A7 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 49660 Da |
| Gene ID | 84385 |
|---|---|
| Other Names | NR1I2; SAR; PAR1; PAR2; PRR; BXR; ONR1; PAR; PARq; SXR; Nuclear Receptor Subfamily 1, Group I, Member 2; Steroid and xenobiotic receptor; Pregnane X receptor |
| Target/Specificity | Rattus norvegicus (Rat) |
| Dilution | WB~~Western blotting: 0.2-2 µg/mL;1:250-2500
Immunohistochemistry: 5-20 µg/mL;1:25-100 Immunocytochemistry: 5-20 µg/mL;1:25-100 Optimal working dilutions must be determined by end user. |
| Format | PBS, pH7.4, containing 0.02% NaN3, 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Nr1i2 |
|---|---|
| Synonyms | Pxr |
| Function | Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. Activated by a broad range of endogenous steroids (e.g. pregnenolone, progesterone) and xenobiotics, including the antibiotic rifampicin and certain plant- derived metabolites. Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation. Target genes include cytochrome P450 enzymes such as CYP3A4 and ATP-binding cassette transporters including ABCB1/MDR1. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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