癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Polyclonal Antibody to Defensin Alpha 6, Paneth Cell Specific (DEFa6)
Defensin Alpha 6, Paneth Cell Specific
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q01524 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 10975 Da |
| Gene ID | 1671 |
|---|---|
| Other Names | DEF6; Defensin-6 |
| Target/Specificity | Homo sapiens (Human) |
| Dilution | WB~~Western blotting: 0.5-2 µg/mL;1:160-660<br/>Immunohistochemistry: 5-20 µg/mL;1:16-66<br/>Immunocytochemistry: 5-20 µg/mL;1:16-66<br/>Optimal working dilutions must be determined by end user. |
| Format | 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DEFA6 |
|---|---|
| Synonyms | DEF6 |
| Function | Host-defense peptide that contributes to intestinal innate immunity and mediates homeostasis at mucosal surfaces by forming higher-order oligomers that capture bacteria and prevent microbial invasion of the epithelium (PubMed:15616305, PubMed:17088326, PubMed:25158166, PubMed:25354318, PubMed:28026958). After binding to bacterial surface proteins, undergoes ordered self-assembly to form fibril-like nanonets that surround and entangle bacteria and thereby prevent bacterial invasion across the epithelial barrier (PubMed:22722251). Entangles and agglutinates Gram-negative bacteria, such as E.coli, S.typhimurium and Y.enterocolitica, and Gram-positive bacteria such as L.monocytogenes, thereby protecting the intestine against invasion by enteric bacterial pathogens (PubMed:22722251, PubMed:25158166, PubMed:27076903). Blocks adhesion of C.albicans to intestinal epithelial cells and thereby suppresses fungal invasion of epithelial cells and biofilm formation (PubMed:28026958). Under reducing conditions and in an acidic environment similar to the intestinal milieu, exhibits inhibitory activity against anaerobic bacteria such as B.adolescentis, L.acidophilus and B.breve, as well as B.longum and S.thermophilus, possibly by leading to alterations in bacterial cell envelope structures (PubMed:25354318). The disulfide- linked oxidized form exhibits negligible antimicrobial activity against Gram-negative and Gram-positive bacteria, as compared to the enteric defensin DEFA5 (PubMed:15616305, PubMed:17088326). |
| Cellular Location | Secreted. Cytoplasmic vesicle, secretory vesicle Note=Stored as propeptide in secretory granules of small intestinal Paneth cells and found in the ileum lumen as mature peptide |
| Tissue Location | Expressed in Paneth cells of the small intestine (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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