癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Polyclonal Antibody to Transferrin Receptor (TFR)
Transferrin Receptor
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q90997 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 85659 Da |
| Gene ID | 396191 |
|---|---|
| Other Names | CD71; TFR1; P90; TFRC; T9; Trfr; sTfR; Transferrin receptor protein 1, serum form |
| Target/Specificity | Chicken (Gallus) |
| Dilution | WB~~Western blotting: 0.5-2 µg/mL;1:110-460<br/>Immunohistochemistry: 5-20 µg/mL;1:11-46<br/>Immunocytochemistry: 5-20 µg/mL;1:11-46<br/>Optimal working dilutions must be determined by end user. |
| Format | 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TFRC |
|---|---|
| Function | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P02786}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P02786} Melanosome {ECO:0000250|UniProtKB:P02786} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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