癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Polyclonal Antibody to Acid Phosphatase 5, Tartrate Resistant (ACP5)
Acid Phosphatase 5, Tartrate Resistant
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | O97860 |
| Reactivity | Rabbit |
| Host | Guinea Pig |
| Clonality | Polyclonal |
| Calculated MW | 36624 Da |
| Gene ID | 100008599 |
|---|---|
| Other Names | TRAP; TrATPase; Tartrate Resistant Acid Phosphatase; Type 5 acid phosphatase |
| Target/Specificity | Oryctolagus cuniculus (Rabbit) |
| Dilution | WB~~Western blotting: 0.5-2 µg/mL; Immunohistochemistry: 5-20 µg/mL; Immunocytochemistry: 5-20 µg/mL; Optimal working dilutions must be determined by end user. |
| Format | PBS, pH7.4, containing 0.02% NaN3, 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ACP5 |
|---|---|
| Function | Functions as a binuclear Fe(III)-Fe(II) acid phosphatase that hydrolyzes phosphate esters to alcohols and phosphate under acidic conditions (By similarity). Dephosphorylates a broad range of substrates, including adenosine 5'-diphosphate (ADP), adenosine 5'- triphosphate (ATP), as well as larger phosphoproteins such as osteopontin (SPP1), a highly phosphorylated bone matrix protein, bone sialoprotein (IBSP) and synthetic compounds such as para-nitrophenyl phosphate (p-NPP). Through the dephosphorylation of bone matrix proteins, plays a crucial role in normal cartilage mineralization during skeletal development and in maintaining and remodeling bone integrity in adults. Promotes osteoclast migration by dephosphorylating SPP1, which binds osteoclasts to the bone matrix. Also involved in immune regulation and macrophage function, contributes to the breakdown of internalized pathogens within lysosomes (By similarity). Regulates immune cell recruitment during infection, partly via interaction with SPP1 (By similarity). May contribute to the removal of mannose-6- phosphate (Man6P) from lysosomal proteins after their delivery to lysosomes, acting in concert with ACP2. The uncleaved form (isoform 5a) functions primarily in immune regulation rather than bone resorption (By similarity). |
| Cellular Location | Lysosome {ECO:0000250|UniProtKB:Q05117}. Secreted {ECO:0000250|UniProtKB:P13686}. Note=The uncleaved form (isoform 5a) is secreted by macrophage and dendritic cell. The cleaved form (isoform 5b) is secreted by osteoclasts. {ECO:0000250|UniProtKB:P13686} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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