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Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 4 (TRPM4)
Transient Receptor Potential Cation Channel Subfamily M, Member 4
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9ESQ5 |
| Reactivity | Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 135341 Da |
| Gene ID | 171143 |
|---|---|
| Other Names | TRPM4B; Melastatin-4; Calcium-activated non-selective cation channel 1; Long transient receptor potential channel 4 |
| Target/Specificity | Rattus norvegicus (Rat) |
| Dilution | WB~~Western blotting: 0.5-2 µg/mL;<br/>Immunohistochemistry: 5-20 µg/mL;<br/>Immunocytochemistry: 5-20 µg/mL;<br/>Optimal working dilutions must be determined by end user. |
| Format | PBS, pH7.4, containing 0.02% NaN3, 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Trpm4 |
|---|---|
| Synonyms | Ltrpc4 |
| Function | Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane (PubMed:16966582, PubMed:19945433). It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (By similarity). |
| Cellular Location | [Isoform 1]: Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TD43}. Endoplasmic reticulum. Golgi apparatus |
| Tissue Location | Isoform 1 is highly expressed in the testis with a moderate expression in the brain, spleen and thymus. Isoform 2 is only expressed in the brain and spleen. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP74692
