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> 首页 > 产品 > 一抗 > 其他 > Polyclonal Antibody to UDP Glucuronosyltransferase 2 Family, Polypeptide B7 (UGT2B7)
Polyclonal Antibody to UDP Glucuronosyltransferase 2 Family, Polypeptide B7 (UGT2B7)
UDP Glucuronosyltransferase 2 Family, Polypeptide B7
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q62789 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 60089 Da |
| Gene ID | 286989 |
|---|---|
| Other Names | UGTB2B9; UDPGTh-2; 3, 4-catechol estrogen-specific UDPGT |
| Target/Specificity | Rattus norvegicus (Rat) |
| Dilution | WB~~Western blotting: 0.2-2 µg/mL;1:250-2500
Immunohistochemistry: 5-20 µg/mL;1:25-100 Immunocytochemistry: 5-20 µg/mL;1:25-100 Optimal working dilutions must be determined by end user. |
| Format | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ugt2b7 {ECO:0000312|RGD:708417} |
|---|---|
| Synonyms | Ugt2b8 |
| Function | UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE, PGE2, PGB1 and F2-isoprostanes (8-iso- PGF2alpha and 5-epi-5-F2t-IsoP). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II. Also metabolizes mycophenolate, an immunosuppressive agent. |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P16662}; Single-pass membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP74708
