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Polyclonal Antibody to ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1a1)
ATPase, Na+/K+ Transporting Alpha 1 Polypeptide
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- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9N0Z6 |
| Reactivity | Rabbit |
| Host | Guinea Pig |
| Clonality | Polyclonal |
| Calculated MW | 112994 Da |
| Gene ID | 100302415 |
|---|---|
| Other Names | Sodium pump subunit alpha-1; Na(+)/K(+) ATPase alpha-1 subunit; Sodium/potassium-transporting ATPase subunit alpha-1 |
| Target/Specificity | Oryctolagus cuniculus (Rabbit) |
| Dilution | WB~~Western blotting: 0.5-2 µg/mL;1:500-2000<br/>Immunohistochemistry: 5-20 µg/mL;1:50-200<br/>Immunocytochemistry: 5-20 µg/mL;1:50-200<br/>Optimal working dilutions must be determined by end user. |
| Format | 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ATP1A1 |
|---|---|
| Function | Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function (PubMed:11738066). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8VDN2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P05023}. Basolateral cell membrane {ECO:0000250|UniProtKB:P06685}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P05023}. Cell membrane; Multi-pass membrane protein; Lumenal side. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P05023}; Multi-pass membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:P06685} Melanosome {ECO:0000250|UniProtKB:P05023}. Note=Expressed at the luminal side of the endocardial endothelium |
| Tissue Location | Expressed in endocardial endothelial cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP74726
