癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Polyclonal Antibody to Transition Protein 2 (TNP2)
Transition Protein 2
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P11378 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 13117 Da |
| Gene ID | 21959 |
|---|---|
| Other Names | TP2; During Histone To Protamine Replacement; Nuclear transition protein 2 |
| Target/Specificity | Mus musculus (Mouse) |
| Dilution | WB~~Western blotting: 0.5-2 µg/mL; Immunohistochemistry: 5-20 µg/mL; Immunocytochemistry: 5-20 µg/mL; Optimal working dilutions must be determined by end user. |
| Format | PBS, pH7.4, containing 0.02% NaN3, 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Tnp2 {ECO:0000312|MGI:MGI:98785} |
|---|---|
| Function | Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:15083521, PubMed:15163613, PubMed:15189834, PubMed:28366643). In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). The histone H2AB1-H2BC1/TH2B dimer is required for loading of TNP2 onto chromatin (PubMed:28366643). |
| Cellular Location | Nucleus. Chromosome. Note=Loaded onto the nucleosomes of condensing spermatids (PubMed:28366643). Inclusion of the H2AB1- H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition protein TNP2 (PubMed:28366643). Nuclear import is mediated by IPO4. Nucleolar localization requires the protein to be phosphorylated (By similarity). {ECO:0000250|UniProtKB:P11101, ECO:0000269|PubMed:28366643} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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