ELOVL5 Rabbit mAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, ICC
Primary Accession	Q9NYP7
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal Antibody
Calculated MW	35293 Da

Protein Information
Name	ELOVL5 {ECO:0000255\|HAMAP-Rule:MF_03205}
Synonyms	ELOVL2
Function	Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity) (PubMed:10970790, PubMed:20937905). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity).
Cellular Location	Endoplasmic reticulum membrane {ECO:0000255\|HAMAP-Rule:MF_03205, ECO:0000269\|PubMed:20937905}; Multi- pass membrane protein {ECO:0000255\|HAMAP-Rule:MF_03205}. Cell projection, dendrite {ECO:0000255\|HAMAP-Rule:MF_03205, ECO:0000269\|PubMed:25065913}. Note=In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree {ECO:0000255\|HAMAP-Rule:MF_03205, ECO:0000269\|PubMed:25065913}
Tissue Location	Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum.