癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Desmocollin 3 Rabbit mAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, FC |
|---|---|
| Primary Accession | Q14574 |
| Reactivity | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Purification | Affinity Purified |
| Calculated MW | 99969 Da |
| Gene ID | 1825 |
|---|---|
| Other Names | DSC3 |
| Dilution | WB~~1:500-1:1000 FC~~1:10~50 |
| Format | Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Name | DSC3 |
|---|---|
| Synonyms | CDHF3, DSC4 |
| Function | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome {ECO:0000250|UniProtKB:P55850} Cytoplasm {ECO:0000250|UniProtKB:P55850}. Note=Expressed in the cytoplasm and at the cell membrane of oocytes {ECO:0000250|UniProtKB:P55850} |
| Tissue Location | Expressed throughout the basal and spinous layer of the epidermis with weak expression in the granular layer (at protein level) (PubMed:19717567, PubMed:7665906). Also expressed in the buccal mucosa, esophagus and cervix (at protein level) (PubMed:7665906) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Desmocollin-3 (DSC3), also known as CDHF3 and DSC4, is a member of the cadherin superfamily of calcium-dependent cell adhesion molecules and a major component of desmosomes. It has 2 isoforms with molecular masses of 100 and 93 kDa. It is particularly expressed in the vagina, testis, skin, oral mucosa and esophagus. Its subcellular localization is at the cell membrane. Post-translational modifications, including glycosylation, have been described.
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