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>   首页   >   产品   >   一抗   >   精选抗体   >   磷酸化抗体   >   Phospho-4E BP1 (Thr46) Rabbit mAb   

Phospho-4E BP1 (Thr46) Rabbit mAb

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, IP
Primary Accession Q13541
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal Antibody
Calculated MW 12580 Da
Additional Information
Gene ID 1978
Other Names EIF4EBP1
Dilution WB~~1/500-1/1000
IHC-P~~N/A
IP~~N/A
Format Liquid
Protein Information
Name EIF4EBP1
Function Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Cellular Location Cytoplasm. Nucleus. Note=Localization to the nucleus is unaffected by phosphorylation status. {ECO:0000250|UniProtKB:Q60876}
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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