Phospho-4E BP1 (Thr46) Rabbit mAb
- 产品详情
- 实验流程
Application ![]()
| WB, IHC-P, IP |
---|---|
Primary Accession | Q13541 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 12580 Da |
Gene ID | 1978 |
---|---|
Other Names | EIF4EBP1 |
Dilution | WB~~1/500-1/1000 IHC-P~~N/A IP~~N/A |
Format | Liquid |
Name | EIF4EBP1 |
---|---|
Function | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. |
Cellular Location | Cytoplasm. Nucleus. Note=Localization to the nucleus is unaffected by phosphorylation status. {ECO:0000250|UniProtKB:Q60876} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.

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