BACE1 Rabbit mAb
- 产品详情
- 实验流程
Application ![]()
| WB, IP |
---|---|
Primary Accession | P56818 |
Reactivity | Rat |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 55748 Da |
Gene ID | 23821 |
---|---|
Other Names | Bace1 |
Dilution | WB~~1/500-1/1000 IP~~N/A |
Format | Liquid |
Name | Bace1 {ECO:0000312|MGI:MGI:1346542} |
---|---|
Synonyms | Bace |
Function | Responsible for the proteolytic processing of the amyloid precursor protein (APP) (PubMed:29325091). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:29325091). Cleaves CHL1 (PubMed:29325091). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P56817}; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum {ECO:0000250|UniProtKB:P56817}. Endosome. Late endosome. Early endosome. Cell surface. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P56817}. Membrane raft. Lysosome Recycling endosome. Cell projection, axon. Cell projection, dendrite. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (By similarity). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine which blocks targeting to late endosomes and lysosomes (PubMed:25592972). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (By similarity) {ECO:0000250|UniProtKB:P56817, ECO:0000269|PubMed:25592972} |
Tissue Location | Expressed in the brain, specifically in neurons and astrocytes (at protein level). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.

终于等到您。ABCEPTA(百远生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问,联系:0512-88856768 tech-china@abcepta.com.
¥ 1,500.00
Cat# AP75137