癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CDK10 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 4
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q15131 |
| Other Accession | Q3UMM4 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41038 Da |
| Antigen Region | 1-32 aa |
| Gene ID | 8558 |
|---|---|
| Other Names | Cyclin-dependent kinase 10, Cell division protein kinase 10, Serine/threonine-protein kinase PISSLRE, CDK10 |
| Target/Specificity | This CDK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-32 amino acids from the N-terminal region of human CDK10. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CDK10 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDK10 |
|---|---|
| Function | Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747). |
| Cellular Location | Cytoplasm, cytoskeleton, cilium basal body |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CDK10 belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase.
REFERENCES
Crawford, J., et al., Genomics 56(1):90-97 (1999).
Brambilla, R., et al., Oncogene 9(10):3037-3041 (1994).
Grana, X., et al., Oncogene 9(7):2097-2103 (1994).
Morgan, D. O. Annu. Rev. Cell Dev. Biol. 13, 261 (1997)
Sherr, C. Science 274:1672 (1996)
Kamb A. TIG 11:136 (1995)
Zhang, H. et al, Cell 82, 915 (1995)
Parge, HE. et al., Science 262, 387 (1993)
Hershko, A. et al., Ann. Rev. Biochem. 61, 761 (1992)
Peters, JM. Curr. Biol. 10, 759 (1998)
Skowyra, D. etal., Cell 91, 209 (1997)
Ganoth D. et al., Nature Cell Biol. 3, 321-324 (2001)
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