Phospho-Dishevelled 2 (Ser143) Rabbit mAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB
Primary Accession	O14641
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Monoclonal Antibody
Calculated MW	78948 Da

Protein Information
Name	DVL2
Function	Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C- terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
Cellular Location	Cell membrane {ECO:0000250\|UniProtKB:Q60838}; Peripheral membrane protein {ECO:0000250\|UniProtKB:Q60838}; Cytoplasmic side {ECO:0000250\|UniProtKB:Q60838}. Cytoplasm, cytosol. Cytoplasmic vesicle {ECO:0000250\|UniProtKB:Q60838}. Nucleus Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136) {ECO:0000250\|UniProtKB:Q60838, ECO:0000269\|PubMed:24616100, ECO:0000269\|PubMed:25805136}

Research Areas