FKBP51 Rabbit mAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IP
Primary Accession	Q13451
Reactivity	Hamster
Host	Rabbit
Clonality	Monoclonal Antibody
Calculated MW	51212 Da

Protein Information
Name	FKBP5
Synonyms	AIG6, FKBP51 {ECO:0000303\|PubMed:2814727
Function	Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277, PubMed:28363942). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production (PubMed:26101251, PubMed:31434731).
Cellular Location	Cytoplasm {ECO:0000250\|UniProtKB:Q64378}. Nucleus {ECO:0000250\|UniProtKB:Q64378}
Tissue Location	Widely expressed, enriched in testis compared to other tissues