癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FNDC5 Rabbit mAb
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- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q8NAU1 |
| Reactivity | Rat, Human, Mouse |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Purification | Affinity Purified |
| Calculated MW | 28283 Da |
| Gene ID | 252995 |
|---|---|
| Other Names | FNDC5 |
| Dilution | WB~~1:1000-1:5000 |
| Format | Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FNDC5 |
|---|---|
| Synonyms | FRCP2 |
| Function | [Irisin]: Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. |
| Cellular Location | [Fibronectin type III domain-containing protein 5]: Cell membrane; Single-pass membrane protein. Peroxisome membrane {ECO:0000250|UniProtKB:Q8K4Z2}; Single-pass membrane protein. Note=Imported into peroxisomes through the PEX5 receptor pathway. {ECO:0000250|UniProtKB:Q8K4Z2} |
| Tissue Location | Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
fibronectin type III domain containing 5(FNDC5) encodes 23 kDa protein, which is a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. Exercise-induced FNDC5 gene expression in muscles was accompanied by a parallel increase in the concentration of circulating irisin, which in turn activates adipocyte thermogenic programs, leading to mitochondrial heat production and energy expenditure.
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