癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PTPN7 Antibody (S44) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P35236 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40529 Da |
| Antigen Region | 22-51 aa |
| Gene ID | 5778 |
|---|---|
| Other Names | Tyrosine-protein phosphatase non-receptor type 7, Hematopoietic protein-tyrosine phosphatase, HEPTP, Protein-tyrosine phosphatase LC-PTP, PTPN7 |
| Target/Specificity | This PTPN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-51 amino acids from human PTPN7. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PTPN7 Antibody (S44) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PTPN7 |
|---|---|
| Function | Protein phosphatase that acts preferentially on tyrosine- phosphorylated MAPK1. Plays a role in the regulation of T and B- lymphocyte development and signal transduction. |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton |
| Tissue Location | Expressed exclusively in thymus and spleen. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PTPN7 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN7 is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP has been shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which is thought to function through dephosphorylating the molecules related to MAP kinase pathway.
REFERENCES
Eswaran,J., Biochem. J. 395 (3), 483-491 (2006)
Mustelin,T., J. Mol. Biol. 354 (1), 150-163 (2005)
Pettiford,S.M., Leukemia 17 (2), 366-378 (2003)
Kosaki,K., J. Clin. Endocrinol. Metab. 87 (8), 3529-3533 (2002)
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